XAGE2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09007(XAGE2 Antibody) at dilution 1/220. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09007(XAGE2 Antibody) at dilution 1/220. (Original magnification: ×200)    

  
  

XAGE2 (X antigen family member 2) is a cancer-testis antigen (CTA) predominantly expressed in normal testicular germ cells but silenced in most somatic tissues. Its aberrant overexpression has been observed in various malignancies, including lung, prostate, and breast cancers, making it a potential biomarker and therapeutic target. XAGE2 belongs to the GAGE/XAGE family, which shares conserved domains and is implicated in tumorigenesis, immune evasion, and metastasis. The XAGE2 antibody is a critical tool for detecting and studying this protein’s role in cancer biology.

Research suggests XAGE2 may promote tumor progression by modulating immune responses or cellular signaling pathways. Its restricted expression in healthy tissues and reactivation in tumors render it an attractive target for immunotherapy, such as cancer vaccines or T-cell-based therapies. XAGE2 antibodies are used in immunohistochemistry, Western blotting, and ELISA to assess protein expression patterns in clinical samples, aiding in cancer diagnosis and prognosis. Recent studies also explore its utility in liquid biopsies for non-invasive cancer monitoring. However, the functional mechanisms of XAGE2 in oncogenesis remain incompletely understood, necessitating further investigation. The development and validation of specific XAGE2 antibodies continue to support translational research, bridging gaps between basic science and clinical applications in oncology.