WRAP53抗体—艾普蒂 新品

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: HT-29, hela and A431 cell, Primary antibody: P08999(WRAP53 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P08999(WRAP53 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

WRAP53 (WD40-encoding RNA Antisense to p53), also known as WRAP53β or TCAB1. is a multifunctional protein encoded by the WRAP53 gene, which produces antisense RNA transcripts regulating p53 expression. Initially identified as a natural antisense transcript stabilizing p53 mRNA, WRAP53 protein plays critical roles in DNA repair, telomere maintenance, and Cajal body formation. Structurally, it contains WD40 repeats that mediate protein-protein interactions. WRAP53 recruits telomerase to Cajal bodies via its interaction with telomerase RNA (TERC), facilitating telomere elongation. It also participates in homologous recombination repair by localizing to DNA damage sites and interacting with proteins like BRCA1 and RAD51.

Antibodies targeting WRAP53 are essential tools for studying its localization, expression, and interactions in cellular processes. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate WRAP53's roles in cancer biology, aging, and genomic stability. Dysregulation of WRAP53 is linked to diseases, including cancers (e.g., head and neck squamous cell carcinoma) and dyskeratosis congenita, a telomere maintenance disorder. Research utilizing WRAP53 antibodies has revealed its dual oncogenic and tumor-suppressive potential, depending on cellular context and p53 status. These antibodies also aid in exploring therapeutic strategies targeting telomerase activity or DNA repair pathways.