CFAP52抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08994(CFAP52 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08994(CFAP52 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CFAP52 antibody targets the Cilia and Flagella Associated Protein 52 (CFAP52), a protein predominantly expressed in tissues with motile cilia or flagella, such as the testis, respiratory tract, and fallopian tubes. CFAP52 is critical for the structural integrity and function of these organelles, particularly in sperm flagella assembly and ciliary motility. It interacts with other ciliary proteins, including components of the dynein regulatory complex, to regulate microtubule sliding and coordinated ciliary beating.

Research on CFAP52 has gained attention due to its association with male infertility, as mutations in the CFAP52 gene are linked to sperm flagellar defects and impaired motility. Antibodies against CFAP52 are essential tools for studying ciliopathies—genetic disorders affecting cilia—such as primary ciliary dyskinesia (PCD) and congenital infertility. These antibodies enable the localization of CFAP52 in tissues via immunohistochemistry (IHC), immunofluorescence (IF), or Western blot (WB), aiding in the diagnosis and mechanistic exploration of ciliary dysfunction.

Recent studies also suggest CFAP52's potential role beyond reproduction, including respiratory health and embryonic development. The antibody serves as a biomarker in both basic research and clinical investigations, bridging molecular insights with therapeutic strategies for cilia-related disorders.