VPS53抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A172 cell, Primary antibody: P08978(VPS53 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P08978(VPS53 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

VPS53 antibody is a research tool designed to detect VPS53. a key component of the endosomal-lysosomal trafficking machinery. VPS53 (Vacuolar Protein Sorting 53) is part of the EARP (Endosome-Associated Recycling Protein) complex, which facilitates retrograde transport of proteins and lipids from endosomes to the trans-Golgi network. This process is critical for maintaining cellular homeostasis, receptor recycling, and lysosomal function. Dysregulation of VPS53-mediated trafficking is linked to various disorders, including neurodegenerative diseases, metabolic defects, and lysosomal storage disorders such as pontocerebellar hypoplasia.

The VPS53 antibody is widely used in molecular and cell biology research to study intracellular transport mechanisms, protein localization, and disease pathogenesis. It enables detection of VPS53 expression levels via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers also utilize this antibody to investigate genetic mutations or altered expression of VPS53 in model organisms or patient-derived cells, providing insights into its role in cellular physiology and pathology.

Commercially available VPS53 antibodies are typically developed in hosts like rabbits or mice, often validated for specificity and application compatibility. Its utility spans basic research on membrane trafficking to translational studies exploring therapeutic targets for VPS53-associated diseases.