VASH2抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and 293T cell, Primary antibody: P08967(VASH2 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

Vasohibin-2 (VASH2) is a member of the vasohibin protein family, initially identified as a regulator of angiogenesis. Unlike its homolog VASH1. which primarily inhibits angiogenesis, VASH2 is implicated in promoting blood vessel formation, particularly in pathological conditions such as cancer. It is expressed in endothelial cells, certain immune cells, and various tumor tissues. VASH2 modulates microtubule dynamics by interacting with small vasohibin-binding protein (SVBP), facilitating microtubule detyrosination—a post-translational modification critical for cellular motility and invasion. This activity links VASH2 to tumor progression, metastasis, and resistance to anti-angiogenic therapies.

VASH2 antibodies are immunological tools used to detect and study the expression, localization, and function of VASH2 in research settings. They are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate VASH2's role in diseases, especially cancers. Studies suggest that elevated VASH2 levels correlate with poor prognosis in malignancies, including hepatocellular carcinoma and glioblastoma, making it a potential therapeutic target. However, its dual roles in physiological and pathological angiogenesis remain under investigation. Commercially available VASH2 antibodies are typically validated for specificity against human, mouse, or rat isoforms, aiding mechanistic studies of vascular biology and tumor microenvironment interactions.