VASH1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: P08966(VASH1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08966(VASH1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The vasohibin-1 (VASH1) antibody is a tool used to detect VASH1. a protein encoded by the *VASH1* gene, which plays a critical role in regulating angiogenesis. Initially identified as an endogenous angiogenesis inhibitor, VASH1 is expressed predominantly in vascular endothelial cells and is induced by pro-angiogenic factors like VEGF. It counteracts excessive blood vessel formation by modulating endothelial cell migration and tubule remodeling, often through interactions with its binding partner small vasohibin-binding protein (SVBP). VASH1 also participates in microtubule detyrosination, influencing cellular dynamics beyond angiogenesis.

Antibodies against VASH1 are widely utilized in research to study its expression, localization, and function in physiological and pathological contexts. For example, they help investigate VASH1's dual role in cancer—acting as both a tumor suppressor by limiting vascularization and a potential promoter of metastasis through mechanisms involving cell motility. These antibodies are applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of VASH1 has been linked to diseases such as retinopathy, atherosclerosis, and inflammatory disorders, making its study relevant for therapeutic development. Commercial VASH1 antibodies are typically validated for specificity across human, mouse, and rat samples, aiding translational research. Ongoing studies explore its diagnostic or prognostic value in vascular-related pathologies.