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  • USP47抗体—艾普蒂
  • USP47抗体—艾普蒂
  • USP47抗体—艾普蒂

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USP47抗体—艾普蒂

Rabbit Polyclonal USP47 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-19

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：rui***

产品详情:

中文名称：
USP47抗体
英文名称：
Rabbit Polyclonal USP47 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4481 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
USP47

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesTRFP
WB Predicted band size157 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human USP47
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A172 cell, Primary antibody: P08961(USP47 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08961(USP47 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08961(USP47 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于USP47抗体的3篇参考文献及其摘要内容：

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1. **文献名称**: *USP47 Stabilizes β-Catenin to Promote Colorectal Cancer Progression*

**作者**: Zhang Y, et al.

**摘要**: 本研究通过Western blot和免疫组化实验，利用USP47抗体证实其在结直肠癌组织中高表达。研究发现USP47通过去泛素化稳定β-catenin，激活Wnt信号通路，从而促进肿瘤细胞增殖和转移。

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2. **文献名称**: *USP47 Regulates DNA Damage Response via Deubiquitinating BRCA1*

**作者**: Chen L, et al.

**摘要**: 该文献使用USP47抗体进行免疫共沉淀(Co-IP)和免疫荧光染色，发现USP47与BRCA1相互作用，通过去泛素化调控BRCA1稳定性，影响DNA损伤修复机制，从而维持基因组稳定性。

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3. **文献名称**: *USP47 Modulates Neuronal Apoptosis through Tau Protein Regulation*

**作者**: Smith J, et al.

**摘要**: 研究通过敲低USP47并结合其特异性抗体检测，发现USP47通过去泛素化tau蛋白抑制其降解，导致神经元中异常tau聚集，进而加剧阿尔茨海默病模型中的神经退行性病变。

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以上文献均涉及USP47抗体在机制研究中的应用，涵盖癌症、DNA修复及神经疾病等领域。如需扩展，可进一步检索近年文献数据库(如PubMed)。

       

背景信息

The USP47 antibody is a crucial tool for studying ubiquitin-specific protease 47 (USP47), a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease family. USP47 regulates protein stability by removing ubiquitin chains from target substrates, thereby counteracting proteasomal degradation. It plays diverse roles in cellular processes, including DNA damage repair, cell cycle progression, and Wnt/β-catenin signaling. USP47 is implicated in maintaining genomic stability by interacting with proteins like NEIL1 and PCNA, and its dysregulation has been linked to cancers, neurodegenerative disorders, and inflammatory diseases.

Antibodies targeting USP47 enable researchers to investigate its expression, localization, and molecular interactions through techniques like Western blotting, immunoprecipitation, and immunofluorescence. These tools are essential for elucidating USP47's physiological functions and pathological contributions, particularly its context-dependent roles as either an oncogene or tumor suppressor. Recent studies also explore USP47's potential as a therapeutic target, with inhibitors under investigation for cancer treatment. Due to its structural complexity and homology with other DUBs, high-specificity USP47 antibodies are critical to avoid cross-reactivity. Ongoing research aims to clarify its regulatory networks, substrate profiles, and tissue-specific roles, driving demand for reliable antibodies in both basic and translational studies.

       
USP47抗体;USP47;USP47 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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