USP45抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08960(USP45 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P08960(USP45 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The USP45 antibody is a tool used to study the ubiquitin-specific protease 45 (USP45), a member of the deubiquitinating enzyme (DUB) family. USP45 is implicated in regulating protein stability and function by removing ubiquitin chains from target substrates, a process critical for cellular processes like DNA repair, cell cycle control, and stress response. While less characterized than other DUBs, USP45 is suggested to interact with proteins involved in DNA damage repair pathways, such as FANCI, hinting at a role in maintaining genomic stability. Its expression and activity may also influence pathological conditions, including cancer and neurodegenerative disorders, though mechanistic insights remain limited.

USP45 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes (e.g., catalytic domains or regulatory regions) to enable detection in assays such as Western blotting, immunofluorescence, or immunohistochemistry. These antibodies help researchers explore USP45's expression patterns, subcellular localization, and interaction partners. Validation data, including knockout controls or tissue-specific reactivity, are crucial to confirm specificity. Current research focuses on elucidating USP45's physiological roles, its potential as a biomarker, and therapeutic relevance in diseases linked to dysregulated ubiquitination. Despite progress, further studies are needed to fully unravel USP45's biological significance and clinical applications.