DUSP11抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08957(DUSP11 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

**Background of DUSP11 Antibody**

DUSP11 (Dual Specificity Phosphatase 11), also known as RNA/RNP complex-1-interacting phosphatase (RIP1), is a member of the dual-specificity phosphatase family. Unlike many DUSPs that dephosphorylate mitogen-activated protein kinases (MAPKs), DUSP11 primarily regulates RNA metabolism and processing by targeting phospho-residues in RNA molecules or RNA-associated proteins. It plays a role in modulating RNA splicing, stability, and viral RNA replication by interacting with RNA-protein complexes.

Antibodies against DUSP11 are essential tools for studying its expression, localization, and function in cellular pathways. They enable detection of endogenous DUSP11 in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Research using DUSP11 antibodies has highlighted its involvement in stress responses, cell cycle regulation, and antiviral defense mechanisms. For instance, DUSP11 has been implicated in regulating the replication of certain RNA viruses by dephosphorylating viral RNA, thereby influencing host-pathogen interactions.

Dysregulation of DUSP11 has been linked to cancer and neurological disorders, underscoring its potential as a therapeutic target. Validated DUSP11 antibodies are critical for exploring its molecular mechanisms, substrate specificity, and interactions with RNA-binding proteins. These antibodies are often developed in hosts like rabbits or mice, with specificity confirmed through knockout/knockdown controls to ensure reliability in experimental models.