ALDH3A2抗体—艾普蒂

+ +

•  

   

     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal liver and normal liver tissue, Primary antibody: P08947(ALDH3A2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08947(ALDH3A2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P08947(ALDH3A2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The ALDH3A2 antibody is a crucial tool for studying the aldehyde dehydrogenase 3 family member A2 (ALDH3A2), an enzyme encoded by the ALDH3A2 gene. This enzyme, also known as fatty aldehyde dehydrogenase (FALDH), plays a vital role in lipid metabolism by oxidizing long-chain fatty aldehydes to their corresponding carboxylic acids, thereby preventing toxic aldehyde accumulation. Mutations in ALDH3A2 are linked to Sjögren-Larsson syndrome (SLS), a rare autosomal recessive disorder characterized by ichthyosis, intellectual disability, and spastic paraplegia. ALDH3A2 is predominantly expressed in the endoplasmic reticulum and peroxisomes of various tissues, including the liver, skin, and brain.

ALDH3A2 antibodies are widely used in research to detect protein expression, localization, and quantification in cellular and tissue samples. They aid in elucidating the enzyme's role in lipid homeostasis, oxidative stress response, and its association with metabolic or neurodegenerative diseases. In diagnostics, these antibodies help identify ALDH3A2 deficiencies in suspected SLS cases. Commercially available ALDH3A2 antibodies are typically developed in hosts like rabbits or mice, using immunogenic peptide sequences specific to the enzyme. Validation methods include Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore ALDH3A2's potential involvement in cancer, as altered expression may influence cell proliferation and drug resistance. However, cross-reactivity with other ALDH isoforms remains a consideration, emphasizing the need for rigorous antibody validation. Overall, ALDH3A2 antibodies are indispensable for advancing both basic research and clinical understanding of lipid-related pathologies.