UGT1A10抗体—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HT-29 cell lysate, Primary antibody: P08941(UGT1A10 Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 seconds    

  
  

The UGT1A10 antibody is a crucial tool for studying the UDP-glucuronosyltransferase (UGT) 1A10 enzyme, a member of the UGT superfamily involved in phase II drug metabolism. UGT enzymes catalyze the conjugation of glucuronic acid to endogenous compounds (e.g., bilirubin, steroids) and xenobiotics (e.g., drugs, environmental toxins), enhancing their water solubility for excretion. UGT1A10 is primarily expressed in extrahepatic tissues, including the gastrointestinal tract, liver, and adrenal glands, playing a role in detoxification and hormone regulation.

This antibody is widely used to detect UGT1A10 protein expression in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It helps investigate tissue-specific expression patterns, enzyme localization, and regulatory mechanisms under physiological or pathological conditions, including cancer (e.g., colorectal, hepatic) and metabolic disorders.

Developed in various host species (e.g., rabbit, mouse), UGT1A10 antibodies are validated for specificity to minimize cross-reactivity with other UGT isoforms (e.g., UGT1A1. UGT1A6). Their utility extends to pharmacogenomic studies, where UGT1A10 polymorphisms influence drug efficacy and toxicity. Recent studies also explore its role in chemoresistance, as altered UGT1A10 activity may affect drug metabolism in tumors. Proper controls (e.g., knockout samples) are essential to ensure antibody reliability in experimental settings.