UBL4A抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Hepg2 and Jurkat cell, human fetal brain tissue and hela cell, A431 and PC3 cell, Primary antibody: P08936(UBL4A Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08936(UBL4A Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08936(UBL4A Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The UBL4A (Ubiquitin-like protein 4A) antibody is a research tool used to detect and study the UBL4A protein, a member of the ubiquitin-like protein family. UBL4A, also known as Get5 or MDY2. plays a role in cellular protein quality control, particularly in the tail-anchored (TA) protein biogenesis pathway. It forms part of the BAG6 complex, which assists in the proper targeting of TA proteins to the endoplasmic reticulum (ER) and participates in the degradation of mislocalized polypeptides via the ubiquitin-proteasome system. UBL4A is implicated in ER-associated degradation (ERAD), stress response, and maintaining cellular homeostasis.

Antibodies against UBL4A are essential for investigating its expression, localization, and interactions in various biological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore its regulatory mechanisms. Studies have linked UBL4A dysfunction to diseases such as cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. For example, altered UBL4A expression has been observed in certain tumors, influencing apoptosis and metastasis. Researchers also utilize these antibodies to dissect its role in immune responses, as UBL4A may modulate NF-κB signaling. Commercial UBL4A antibodies are typically validated for specificity across human, mouse, and rat samples, enabling cross-species studies. Ongoing research continues to uncover its multifaceted roles in cellular physiology and pathology.