UBL7抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse testis tissue, Hela cell lysates, Primary antibody: P08934(UBL7 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08934(UBL7 Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

The UBL7 antibody is a tool used to detect ubiquitin-like protein 7 (UBL7), a member of the ubiquitin-like (UBL) protein family. UBL7. also known as ubiquitin-fold modifier 1 (UFM1)-binding protein 1 (UFBP1), plays a role in the UFMylation pathway, a post-translational modification process analogous to ubiquitination. This pathway is involved in endoplasmic reticulum (ER) stress response, ribosome biogenesis, and cellular homeostasis. UBL7 specifically interacts with UFM1. facilitating its conjugation to target proteins, and is critical for maintaining ER integrity and regulating apoptosis under stress conditions.

The UBL7 antibody is commonly used in research to study UBL7 expression, localization, and function in various biological contexts. It has been employed in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to explore UBL7's role in diseases like cancer, neurodegenerative disorders, and metabolic syndromes. Studies suggest UBL7 dysregulation may contribute to tumor progression or neurodegeneration, making it a potential therapeutic target.

Antibodies against UBL7 are typically developed in hosts like rabbits or mice, using immunogenic peptides derived from conserved regions of the protein. Validation often includes knockout cell lines or tissue-specific expression analyses to confirm specificity. Commercial UBL7 antibodies are widely available, supporting both basic and translational research into UFMylation mechanisms and associated pathologies.