DNAJB11抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04438(ROS1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

DNAJ homolog subfamily B member 11 (DNAJB11) is a member of the heat shock protein 40 (HSP40/DNAJ) family, which functions as a co-chaperone for HSP70 proteins. It plays a critical role in protein quality control by assisting in the folding, stabilization, and degradation of client proteins, particularly within the endoplasmic reticulum (ER). DNAJB11 is primarily localized to the ER lumen and is involved in the ER-associated degradation (ERAD) pathway, ensuring proper clearance of misfolded proteins to maintain cellular homeostasis.

Structurally, DNAJB11 contains a conserved J-domain that mediates interaction with HSP70. along with a glycine/phenylalanine-rich (G/F) domain and a C-terminal substrate-binding region. Its activity is crucial for cellular stress responses and has been implicated in diseases linked to protein misfolding, including certain cancers, neurodegenerative disorders, and polycystic kidney diseases. Notably, mutations in the DNAJB11 gene are associated with autosomal dominant tubulointerstitial kidney disease (ADTKD), highlighting its role in renal function.

Antibodies targeting DNAJB11 are widely used in research to study its expression, localization, and interaction networks. They are essential tools for Western blotting, immunohistochemistry, and immunofluorescence to explore DNAJB11's involvement in ER stress, proteostasis, and disease mechanisms. Commercially available DNAJB11 antibodies are typically validated for specificity across human and model organism tissues, aiding in both basic research and clinical investigations of ER-related pathologies.