EIPR1抗体—艾普蒂

The EIPR1 (Endosomal Intracompartmental Protein Regulator 1) antibody is a tool used to study the EIPR1 protein, which plays a role in regulating endosomal trafficking and membrane dynamics. EIPR1 is implicated in coordinating vesicle transport between endosomes and the trans-Golgi network, influencing processes like lysosome biogenesis, autophagy, and cargo sorting. Dysregulation of these pathways is linked to neurodegenerative diseases, cancer, and immune disorders. The antibody, typically developed in rabbit or mouse models using immunogenic peptide sequences or recombinant protein fragments, enables detection of EIPR1 in techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Its specificity is validated via knockout cell lines or siRNA-mediated protein depletion. Research utilizing EIPR1 antibodies has highlighted its interaction with components of the HOPS (Homotypic fusion and Protein Sorting) complex and its role in maintaining endolysosomal integrity. Current studies focus on its involvement in pathological conditions, including viral entry mechanisms and metabolic storage diseases. As a reagent, the EIPR1 antibody aids in elucidating molecular mechanisms of intracellular trafficking, offering potential therapeutic insights for trafficking-related disorders.