TGM5抗体—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue, MCF7 cells, Primary antibody: P08900(TGM5 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08900(TGM5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08900(TGM5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

Transglutaminase 5 (TGM5), a member of the transglutaminase enzyme family, plays a critical role in catalyzing protein cross-linking via ε-(γ-glutamyl)lysine bonds, contributing to epidermal barrier formation and keratinocyte differentiation. TGM5 is predominantly expressed in the epidermis, particularly in the upper layers of stratified squamous epithelia, where it stabilizes the cornified envelope during terminal differentiation. Mutations in the TGM5 gene are linked to autosomal recessive congenital ichthyosis, specifically a form of lamellar ichthyosis, highlighting its importance in maintaining skin integrity.

TGM5 antibodies are essential tools in studying epidermal biology and related disorders. They enable the detection and localization of TGM5 protein in tissues, aiding in the diagnosis of TGM5-associated genetic skin diseases. Researchers use these antibodies in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to explore TGM5 expression patterns, enzymatic activity, and interactions with substrates such as loricrin and involucrin. Additionally, TGM5 antibodies help investigate its role in pathological conditions beyond ichthyosis, including wound healing, inflammation, and cancer, where dysregulated transglutaminase activity may influence disease progression. Commercially available TGM5 antibodies are typically raised in rabbits or mice, targeting specific epitopes to ensure specificity. Their application continues to advance understanding of epidermal differentiation mechanisms and potential therapeutic targets for skin disorders.