TRAK1抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08897(TRAK1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08897(TRAK1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

TRAK1 (Trafficking Kinesin Protein 1), also known as GRIF-1 or OIP106. is a mitochondrial adaptor protein critical for regulating intracellular organelle transport, particularly mitochondrial dynamics and axonal trafficking. It interacts with motor proteins like kinesin and dynein to mediate the movement of mitochondria along microtubules, ensuring proper distribution to cellular regions with high energy demands. Dysregulation of TRAK1 is implicated in neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and schizophrenia, due to its role in maintaining mitochondrial function and synaptic activity.

TRAK1 antibodies are essential tools for studying the protein’s expression, localization, and interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore TRAK1’s involvement in cellular processes and disease mechanisms. Researchers also employ these antibodies to investigate TRAK1’s structural domains, such as its coiled-coil regions and dynein-binding motifs, which facilitate protein-protein interactions.

The development of high-specificity TRAK1 antibodies has advanced studies on mitochondrial trafficking defects and their links to neurodegeneration. Some studies highlight TRAK1’s dual role in mitochondrial fission/fusion and its crosstalk with endoplasmic reticulum networks. As mitochondrial dysfunction is a hallmark of many diseases, TRAK1 antibodies remain pivotal in uncovering therapeutic targets and diagnostic biomarkers.