TNFAIP3抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08891(TNFAIP3 Antibody) at dilution 1/210. (Original magnification: ×200)    

  
  

TNFAIP3 (Tumor Necrosis Factor Alpha-Induced Protein 3), also known as A20. is a ubiquitin-editing enzyme encoded by the TNFAIP3 gene. It plays a critical role in regulating immune and inflammatory responses, primarily by inhibiting the NF-κB signaling pathway. TNFAIP3/A20 achieves this through its dual enzymatic activities: deubiquitinating (via its ovarian tumor domain) and E3 ubiquitin ligase functions (via its zinc finger domains). These activities allow it to modulate key signaling molecules, such as RIPK1 and TRAF6. thereby fine-tuning cellular responses to pro-inflammatory cytokines (e.g., TNF-α) and pathogen-associated molecular patterns (PAMPs).

Antibodies targeting TNFAIP3 are essential tools in studying its expression, localization, and functional mechanisms. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TNFAIP3's role in autoimmune diseases (e.g., rheumatoid arthritis, lupus), cancers (e.g., lymphoma), and inflammatory disorders. Dysregulation of TNFAIP3 has been linked to aberrant NF-κB activation, leading to uncontrolled inflammation or cell death. Research using TNFAIP3 antibodies has highlighted its potential as a therapeutic target or biomarker in diseases characterized by immune dysregulation. However, interpreting results requires caution due to post-translational modifications and tissue-specific expression patterns of TNFAIP3.