TMPRSS11A抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using CD126 mouse mAb against Jurkat (1), MOLT4 (2),Raw264.7 (3) and THP-1 (4) cell lysate.    

  
  

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     Flow cytometric analysis of Jurkat cells using CD126 mouse mAb (green) and negative control (red).    

  
  

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     Flow cytometric analysis of K562 cells using CD126 mouse mAb (green) and negative control (red).    

  
  

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     Flow cytometric analysis of THP-1 cells using CD126 mouse mAb (green) and negative control (red).    

  
  

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     Flow cytometric analysis of U937 cells using CD126 mouse mAb (green) and negative control (red).    

  
  

TMPRSS11A (Transmembrane Serine Protease 11A) is a member of the type II transmembrane serine protease (TTSP) family, characterized by a transmembrane domain, a stem region, and a C-terminal catalytic domain. It is primarily expressed in epithelial tissues, including the respiratory tract, and plays a role in proteolytic activation of proteins involved in cellular processes such as tissue remodeling, signaling, and viral entry. Notably, TMPRSS11A has garnered attention for its potential role in cleaving viral surface proteins, including influenza hemagglutinin and SARS-CoV-2 spike protein, facilitating viral fusion with host cells.

Antibodies targeting TMPRSS11A are critical tools for studying its expression, localization, and function. They enable detection of the protein in tissue samples (via immunohistochemistry or immunofluorescence) and quantification in lysates (via Western blot or ELISA). Such antibodies are also used to investigate its interaction with viral proteins or host substrates, aiding in mechanistic studies of viral pathogenesis and host-pathogen interactions. Additionally, TMPRSS11A antibodies may have therapeutic potential, as blocking its proteolytic activity could inhibit viral entry.

Research applications extend to cancer biology, where TMPRSS11A overexpression has been observed in certain tumors, suggesting a role in tumor progression. Validated antibodies are essential for distinguishing TMPRSS11A from homologous proteases, ensuring specificity in experimental models. Overall, TMPRSS11A antibodies serve as vital reagents in virology, oncology, and protease biology, supporting both basic research and drug development.