TMPRSS11E抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08886(TMPRSS11E Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08886(TMPRSS11E Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The TMPRSS11E (Transmembrane Protease, Serine 11E) protein is a member of the type II transmembrane serine protease (TTSP) family, characterized by a conserved serine protease domain and involvement in extracellular matrix remodeling, cellular signaling, and viral entry. Primarily expressed in epithelial tissues, TMPRSS11E shares structural homology with other TTSPs like TMPRSS2. which is known for its role in SARS-CoV-2 infection. While its exact physiological function remains under investigation, TMPRSS11E is hypothesized to participate in proteolytic activation of viral glycoproteins or host receptors, potentially influencing respiratory virus pathogenesis.

Antibodies targeting TMPRSS11E are valuable tools for studying its expression, localization, and interaction mechanisms. They enable detection via techniques such as immunohistochemistry, Western blotting, and flow cytometry, aiding research into tissue-specific distribution and disease associations. Emerging studies suggest TMPRSS11E may contribute to cancer progression, particularly in lung and prostate malignancies, making its antibodies relevant for biomarker discovery or therapeutic targeting. However, challenges persist in ensuring antibody specificity due to high sequence similarity among TTSPs. Recent interest in TMPRSS11E antibodies has also grown in antiviral drug development, given the protease's potential role in facilitating viral entry, though this requires further validation.