TMED1抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A172 cells, 231 cells, Human normal stomach tissue, Hela cells, Primary antibody: P08878(TMED1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08878(TMED1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08878(TMED1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

TMED1 (Transmembrane emp24 domain-containing protein 1), also known as p24a or EMP24. is a member of the TMED family involved in intracellular protein trafficking and cargo receptor activities. It plays a role in the formation of COPII vesicles, which mediate endoplasmic reticulum (ER)-to-Golgi transport, and is implicated in the selective packaging of secretory proteins. TMED1 is widely expressed in epithelial, immune, and neuronal cells, influencing processes like inflammation, cell differentiation, and signaling pathways such as Wnt/β-catenin.

TMED1 antibodies are essential tools for studying its expression, localization, and function. These antibodies, typically monoclonal or polyclonal (derived from rabbits or mice), are used in techniques including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. They help detect endogenous TMED1 in tissues or cultured cells, aiding research into its physiological and pathological roles.

Dysregulation of TMED1 has been linked to diseases such as cancer, neurodegenerative disorders, and metabolic conditions. In cancer, elevated TMED1 levels correlate with tumor progression, potentially affecting cell migration and angiogenesis. In Alzheimer’s disease, TMED1 may interact with amyloid precursor protein (APP) trafficking. Antibodies against TMED1 thus serve as critical reagents for exploring its diagnostic or therapeutic potential. Recent studies also highlight its role in viral infections (e.g., SARS-CoV-2) by modulating host cell entry pathways, underscoring its broad biomedical relevance.