TLK2抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 293T, HT-29, RAW264.7, LOVO, TM4 cell lysates, Primary antibody: P08876(TLK2 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08876(TLK2 Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

The Tousled-like kinase 2 (TLK2) is a serine/threonine kinase belonging to the Tousled-like kinase (TLK) family, which shares homology with the Arabidopsis Tousled protein involved in development. TLK2. along with its paralog TLK1. plays critical roles in DNA repair, cell cycle regulation, and chromatin remodeling. It phosphorylates downstream targets such as the histone chaperone ASF1A and histone H3 (HIST1H3A), facilitating chromatin assembly during DNA replication and damage response. TLK2 is ubiquitously expressed but shows higher levels in tissues like testes, thymus, and colon, with its activity modulated by stress signals, including DNA damage and oxidative stress.

TLK2-specific antibodies are essential tools for studying its expression, localization, and function. These antibodies enable detection of TLK2 in techniques like Western blotting, immunoprecipitation, and immunohistochemistry. Dysregulation of TLK2 has been implicated in cancer, with studies linking its overexpression or inactivation to tumor progression, therapy resistance, and poor prognosis. For example, TLK2 inhibition sensitizes cancer cells to genotoxic therapies, highlighting its potential as a therapeutic target. However, conflicting reports on TLK2's role in different cancer types underscore the need for context-specific research. Commercial and custom-generated TLK2 antibodies vary in specificity, requiring validation via knockout controls or siRNA knockdown. Ongoing research aims to clarify TLK2's interplay with signaling pathways and its utility as a biomarker or drug target in precision oncology.