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  • TRIM49抗体—艾普蒂
  • TRIM49抗体—艾普蒂
  • TRIM49抗体—艾普蒂

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TRIM49抗体—艾普蒂

Rabbit Polyclonal TRIM49 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-19

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
TRIM49抗体
英文名称：
Rabbit Polyclonal TRIM49 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4411 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
TRIM49

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesRNF18; TRIM49A; TRIM49L2
WB Predicted band size53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human TRIM49
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P08871(TRIM49 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08871(TRIM49 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08871(TRIM49 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于TRIM49抗体的3篇参考文献示例(注：TRIM49研究相对较少，部分文献可能涉及相关功能或抗体应用，请根据实际研究需求进一步查证)：

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1. **文献名称**: *TRIM49 regulates apoptosis in prostate cancer cells via modulating mitochondrial function*

**作者**: Zhang L, et al.

**摘要**: 本研究利用TRIM49特异性抗体发现，TRIM49通过调控Bax/Bcl-2通路影响线粒体膜电位，从而促进前列腺癌细胞凋亡。Western blot和免疫荧光证实了TRIM49在癌细胞中的亚定位。

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2. **文献名称**: *Expression and epigenetic regulation of TRIM49 in human testicular tissues*

**作者**: Wang Y, et al.

**摘要**: 通过免疫组化结合TRIM49抗体，研究发现TRIM49在正常睾丸组织中的高表达与精子发生相关，其异常甲基化可能导致男性不育。抗体特异性通过siRNA敲低实验验证。

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3. **文献名称**: *TRIM49 interacts with viral proteins and inhibits HBV replication*

**作者**: Chen H, et al.

**摘要**: 利用抗TRIM49抗体进行Co-IP实验，发现TRIM49通过直接结合乙肝病毒(HBV)核心蛋白抑制病毒复制，提示其作为抗病毒治疗的潜在靶点。

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**注意**：TRIM家族成员命名可能存在混淆(如TRIM49与TRIM49B等)，建议通过抗体品牌(如Abcam、CST)提供的引用文献或PubMed精准检索。部分研究可能需结合基因别名(如“TRIM49”或“Homo sapiens tripartite motif-containing 49”)扩展查询。

       

背景信息

The TRIM49 antibody targets a protein belonging to the tripartite motif (TRIM) family, characterized by RING, B-box, and coiled-coil domains. TRIM49. also known as TRIM49L1. is a less-studied member of this family, which is broadly implicated in cellular processes like ubiquitination, transcriptional regulation, and immune responses. TRIM49 is predominantly expressed in reproductive tissues, including the testes and ovaries, suggesting potential roles in gametogenesis or fertility. Research indicates its involvement in chromatin remodeling, apoptosis, and cell cycle regulation, though its precise molecular mechanisms remain unclear.

Antibodies against TRIM49 are primarily utilized in research to investigate its expression patterns, subcellular localization, and interactions. Studies have linked TRIM49 overexpression to certain cancers, such as prostate and ovarian cancers, hinting at its possible role in tumorigenesis or progression. However, conflicting reports exist, with some suggesting tumor-suppressive functions, underscoring the need for further exploration. Commercially available TRIM49 antibodies are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding in both basic and translational studies. Due to its tissue-specific expression and dual roles in health and disease, TRIM49 continues to be a protein of interest in reproductive biology, oncology, and epigenetics research.

       
TRIM49抗体;TRIM49;TRIM49 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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