TRIM16抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08868(TRIM16 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The TRIM16 antibody is a research tool used to detect and study TRIM16 (tripartite motif-containing protein 16), a member of the TRIM protein family involved in diverse cellular processes. TRIM16 contains characteristic domains, including a RING finger, B-box, and coiled-coil regions, which enable its roles in protein-protein interactions, ubiquitination, and regulation of cellular pathways. It functions as an E3 ubiquitin ligase, modulating protein degradation, and participates in autophagy, cellular differentiation, and antiviral responses. TRIM16 is also implicated in redox homeostasis by interacting with antioxidant proteins like NRF2.

Research highlights TRIM16’s dual role in cancer, acting as a tumor suppressor in neuroblastoma by promoting apoptosis and inhibiting proliferation, while potentially enhancing metastasis in other cancers. It also contributes to neuronal health by regulating autophagy-mediated clearance of protein aggregates, linking it to neurodegenerative diseases like Alzheimer’s. Additionally, TRIM16 influences epidermal differentiation and skin barrier formation.

The TRIM16 antibody is widely employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to analyze TRIM16 expression, localization, and interactions. Its applications extend to studying TRIM16’s involvement in disease mechanisms, therapeutic target identification, and signaling pathway dissection. However, antibody specificity and validation remain critical to ensure accurate interpretation of experimental results. Ongoing research continues to unravel TRIM16’s multifaceted roles in health and disease.