TXN2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08856(TXN2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08856(TXN2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The TXN2 antibody is a crucial tool for studying thioredoxin 2 (TXN2), a mitochondrial-specific redox protein belonging to the thioredoxin family. TXN2 is primarily localized in the mitochondrial matrix and plays a vital role in maintaining cellular redox homeostasis by scavenging reactive oxygen species (ROS) and regulating oxidative stress. It contains a conserved C-terminal catalytic motif (Cys-Gly-Pro-Cys) and functions in electron transfer, supporting mitochondrial metabolism, apoptosis, and antioxidant defense. TXN2 interacts with mitochondrial proteins like peroxiredoxin 3 and thioredoxin reductase 2. contributing to redox signaling and protecting mitochondrial DNA from oxidative damage.

Antibodies targeting TXN2 are widely used in research to investigate its expression, localization, and interactions in various pathological contexts. For example, they are employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess TXN2 levels in diseases like cancer, neurodegenerative disorders (e.g., Alzheimer's and Parkinson's), cardiovascular diseases, and diabetes. Studies have linked TXN2 dysregulation to mitochondrial dysfunction, impaired energy production, and disease progression, making it a potential therapeutic target. TXN2 antibodies also aid in exploring its role in aging, inflammation, and metabolic syndromes, highlighting its broader impact on cellular health. Researchers rely on these antibodies to validate TXN2's involvement in mitochondrial pathways and its crosstalk with cytosolic redox systems.