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  • LEFTY2抗体—艾普蒂
  • LEFTY2抗体—艾普蒂
  • LEFTY2抗体—艾普蒂

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LEFTY2抗体—艾普蒂

Rabbit Polyclonal LEFTY2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-19

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
LEFTY2抗体
英文名称：
Rabbit Polyclonal LEFTY2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4402 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
LEFTY2

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesEBAF; LEFTA; TGFB4; LEFTYA
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal muscle tissue, Primary antibody: P08851(LEFTY2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08851(LEFTY2 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08851(LEFTY2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于LEFTY2抗体的3篇参考文献的示例(注：文献信息为示例，实际引用请核实原文)：

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1. **文献名称**: "Left-right asymmetry in embryonic development: role of Lefty2 in the mouse"

**作者**: Meno, C. et al.

**摘要**: 该研究利用LEFTY2抗体在小鼠胚胎中检测蛋白表达，发现LEFTY2通过拮抗Nodal信号通路调控胚胎左右轴形成，揭示了其在早期发育中的关键作用。

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2. **文献名称**: "Lefty2 as a biomarker in ovarian cancer progression"

**作者**: Tanaka, M. et al.

**摘要**: 通过免疫组化(使用LEFTY2抗体)分析卵巢癌组织，发现LEFTY2高表达与肿瘤转移和不良预后相关，提示其可作为潜在治疗靶点。

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3. **文献名称**: "Regulation of TGF-β signaling by Lefty2 in human embryonic stem cells"

**作者**: Saijoh, Y. et al.

**摘要**: 研究使用LEFTY2抗体进行蛋白质印迹和免疫荧光实验，证实LEFTY2通过抑制Smad2/3磷酸化调控TGF-β通路，影响人胚胎干细胞的自我更新与分化。

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4. **文献名称**: "Lefty2 antibody-based detection in breast cancer metastasis"

**作者**: Chung, J. et al.

**摘要**: 利用LEFTY2抗体的ELISA和免疫组化方法，发现LEFTY2在乳腺癌转移患者的血清中显著升高，提示其作为液体活检标志物的潜力。

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(注：以上文献为示例，实际研究请参考PubMed或SciFinder等数据库的权威文献。)

       

背景信息

The LEFTY2 antibody is a crucial tool in studying the role of LEFTY2 (Left-Right Determination Factor 2), a secreted protein belonging to the TGF-β (transforming growth factor-beta) superfamily. LEFTY2. also known as endometrial bleeding-associated factor (Ebaf), is primarily involved in embryonic development, particularly in establishing left-right asymmetry during organogenesis. It acts as an antagonist of Nodal and BMP (bone morphogenetic protein) signaling pathways, regulating cell differentiation, tissue patterning, and stem cell maintenance. Dysregulation of LEFTY2 has been linked to developmental disorders, cancer progression, and reproductive health issues, including endometrial remodeling and recurrent pregnancy loss.

LEFTY2 antibodies are widely used in research to detect and quantify LEFTY2 protein expression in various biological samples through techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate LEFTY2's spatial-temporal expression patterns, its interactions with signaling molecules, and its role in pathological conditions. For instance, studies using LEFTY2 antibodies have revealed its tumor-suppressive effects in certain cancers by inhibiting epithelial-mesenchymal transition (EMT), while other research highlights its involvement in immune modulation and tissue fibrosis. The development of specific, high-affinity LEFTY2 antibodies continues to advance our understanding of developmental biology, oncology, and regenerative medicine.

       
LEFTY2抗体;LEFTY2;LEFTY2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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