STX10抗体—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A375 cells, A431 cells, lovo cells, hela cells, Primary antibody: P08832(STX10 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08832(STX10 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08832(STX10 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The STX10 antibody is a research tool designed to target Syntaxin 10 (STX10), a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family involved in intracellular membrane trafficking. Syntaxins are critical for vesicle docking and fusion, mediating transport between organelles. STX10 localizes primarily to the trans-Golgi network (TGN) and endosomes, where it regulates retrograde transport and lipid sorting. It is implicated in maintaining Golgi structure, lysosomal function, and lipid homeostasis, with studies linking it to diseases such as Niemann-Pick type C (NPC), a lysosomal storage disorder.

The STX10 antibody is widely used in molecular and cell biology to investigate protein localization, trafficking pathways, and organelle dynamics. It aids in techniques like Western blotting, immunofluorescence, and immunoprecipitation, helping researchers map STX10’s interactions with other SNAREs (e.g., VAMP4. Syntaxin 16) or regulatory proteins. Commercially available antibodies are typically raised in rabbits or mice, validated for specificity via knockout controls or siRNA knockdown. Recent studies utilize STX10 antibodies to explore its role in metabolic diseases, cancer cell secretion, and neurological disorders, underscoring its importance in understanding cellular logistics and disease mechanisms. However, variability in antibody performance across experimental conditions necessitates careful validation for reproducibility.