SURF6抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: HL-60, K562 and Hela cell lysates, Primary antibody: P08822(SURF6 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P08822(SURF6 Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

The SURF6 antibody is a tool used to study the SURF6 (Surfeit 6) protein, a member of the Surfeit gene cluster. This conserved cluster, found in vertebrates, encodes multiple proteins (SURF1 to SURF6) implicated in diverse cellular processes. SURF6 localizes to the nucleolus and is associated with ribosome biogenesis, specifically in rRNA processing and ribosomal subunit assembly. Its role in cell cycle regulation, proliferation, and potential links to cancer have drawn research interest. Studies suggest SURF6 interacts with nucleolar proteins like NOLC1 and participates in pre-rRNA maturation.

SURF6 antibodies (polyclonal or monoclonal) enable detection and quantification of SURF6 in techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies help explore SURF6's expression patterns across tissues, its subcellular localization, and dysregulation in diseases. Notably, SURF6 overexpression has been observed in certain cancers (e.g., hepatocellular carcinoma), suggesting its potential as a biomarker or therapeutic target. Additionally, research links SURF6 to developmental processes and genetic disorders, though its precise mechanisms remain under investigation. Commercial SURF6 antibodies are often validated for specificity using knockout cell lines or siRNA knockdown. Ongoing studies aim to clarify SURF6's molecular interactions and its broader role in nucleolar function and disease pathology.