SULT2A1抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: P08820(SULT2A1 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08820(SULT2A1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of SULT2A1 Antibody**

The SULT2A1 (sulfotransferase family 2A member 1) antibody is a tool used to detect and study the expression of the SULT2A1 enzyme, a member of the cytosolic sulfotransferase family. SULT2A1 catalyzes the sulfonation of endogenous compounds (e.g., steroids, bile acids) and xenobiotics, facilitating their excretion and modulating biological activity. It is primarily expressed in the liver, adrenal glands, and gastrointestinal tract, playing a critical role in hormone regulation, detoxification, and drug metabolism.

SULT2A1 antibodies are widely employed in research to investigate enzyme localization, expression levels, and function in physiological and pathological contexts. They are validated for techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Specificity is a key consideration; high-quality antibodies should recognize SULT2A1 without cross-reacting with other sulfotransferases (e.g., SULT1A1). Researchers often use these antibodies to explore SULT2A1's role in diseases like hormone-dependent cancers, metabolic disorders, or drug resistance, where altered sulfonation pathways may contribute to pathogenesis.

Commercial SULT2A1 antibodies are typically raised against peptide sequences unique to the human SULT2A1 protein, though reactivity with orthologs (e.g., rodent SULT2A1) varies. Proper controls, including tissue lysates from SULT2A1-knockout models, are recommended to confirm antibody specificity.