STK16抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P08817(STK16 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08817(STK16 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08817(STK16 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The STK16 antibody is a tool used to study the serine/threonine kinase 16 (STK16), also known as MPSK1 or CRIK. STK16 belongs to the mammalian STE20-like kinase family and is involved in various cellular processes, including cell cycle regulation, cytokinesis, and membrane trafficking. Its structure features an N-terminal kinase domain and a C-terminal regulatory region, which may mediate protein interactions or subcellular localization. STK16 activity is modulated by auto-phosphorylation and binding partners, though its precise regulatory mechanisms remain incompletely understood.

Antibodies targeting STK16 enable researchers to detect its expression, localization, and functional roles in biological systems. These antibodies are widely utilized in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry. Due to potential variability in specificity and affinity, validation using knockout controls or orthogonal methods is recommended. Studies employing STK16 antibodies have linked the kinase to cancer progression (e.g., aberrant cell proliferation) and neurodegenerative disorders, suggesting its involvement in disease-related signaling pathways.

Challenges in STK16 research include its low abundance in certain tissues and cross-reactivity risks with structurally similar kinases. Additionally, post-translational modifications may affect antibody binding. Despite these hurdles, STK16 antibodies remain critical for unraveling the kinase's physiological and pathological roles, with implications for developing targeted therapies. Ongoing efforts aim to refine antibody specificity and explore STK16's interaction networks to clarify its mechanistic contributions to cellular homeostasis and disease.