SNX15抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P08793(SNX15 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SNX15 antibody is a research tool designed to detect Sorting Nexin 15 (SNX15), a protein belonging to the sorting nexin family involved in membrane trafficking and cellular signaling. SNX15 contains a phox homology (PX) domain, which facilitates phosphoinositide binding, and plays roles in endosomal sorting, lysosomal function, and receptor degradation pathways. Studies link SNX15 to EGFR trafficking, cholesterol metabolism, and autophagosome-lysosome fusion, with implications in cancer and neurodegenerative diseases.

The antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study SNX15 expression, localization, and interactions. Commercially available SNX15 antibodies are typically developed in hosts like rabbits or mice, using immunogens derived from human or mouse SNX15 sequences. Validation often includes testing in knockout cell lines or tissue samples to confirm specificity.

Research utilizing SNX15 antibodies has helped uncover its regulatory role in endosomal dynamics and its interaction with proteins like retromer complexes or Rab GTPases. Dysregulation of SNX15 has been observed in certain cancers, making it a potential biomarker or therapeutic target. However, antibody performance may vary depending on epitope accessibility, post-translational modifications, or species cross-reactivity, requiring careful experimental optimization.