SLC39A14抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08777(SLC39A14 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The solute carrier family 39 member 14 (SLC39A14), also known as ZIP14. is a transmembrane zinc/iron transporter involved in cellular metal homeostasis. It facilitates the uptake of divalent cations, including zinc (Zn²⁺), iron (Fe²⁺), and manganese (Mn²⁺), across plasma or organellar membranes. SLC39A14 is highly expressed in metabolically active tissues, such as the liver, intestines, and pancreas, where it regulates systemic and local metal distribution. Dysregulation of SLC39A14 has been linked to metabolic disorders (e.g., hemochromatosis, diabetes), neurodegenerative diseases (e.g., Parkinson’s), and cancers due to its role in metal-mediated signaling and oxidative stress.

Antibodies targeting SLC39A14 are critical tools for studying its expression, localization, and function. They enable detection via techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF). Researchers use these antibodies to investigate tissue-specific metal transport mechanisms, disease-associated mutations, and therapeutic targets. For example, studies have utilized SLC39A14 antibodies to identify its upregulation in hepatocellular carcinoma or loss-of-function mutations in manganese toxicity models. Validation of antibody specificity (e.g., knockout controls) is essential due to potential cross-reactivity with other ZIP transporters. Overall, SLC39A14 antibodies advance insights into metal biology and pathologies linked to disrupted ion homeostasis.