SLC25A13抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue, hepg2 cells, Primary antibody: P08772(SLC25A13 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08772(SLC25A13 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08772(SLC25A13 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The SLC25A13 antibody targets the solute carrier family 25 member 13 (SLC25A13) protein, a mitochondrial transporter encoded by the *SLC25A13* gene. This protein, also known as citrin, functions as a calcium-binding mitochondrial aspartate/glutamate carrier (AGC) involved in the malate-aspartate shuttle, facilitating the exchange of aspartate and glutamate across the mitochondrial inner membrane. This process is critical for maintaining cellular redox balance, urea cycle function, and gluconeogenesis.

Mutations in *SLC25A13* are linked to citrin deficiency, an autosomal recessive disorder encompassing neonatal intrahepatic cholestasis (NICCD) and adult-onset type II citrullinemia (CTLN2). These conditions manifest as metabolic disturbances, including hyperammonemia, citrullinemia, and liver dysfunction. SLC25A13 antibodies are essential tools in research to study protein expression, localization, and functional alterations in disease models.

In experimental settings, these antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess citrin levels in tissues (e.g., liver, kidney, heart) and investigate its role in metabolic pathways. Their application aids in diagnosing genetic disorders, elucidating molecular mechanisms of citrin deficiency, and evaluating therapeutic interventions targeting mitochondrial transport dysfunction.