SRPX抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P08771(SRPX Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08771(SRPX Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08771(SRPX Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SRPX (Sushi Repeat-containing Protein X) antibody targets a protein encoded by the SRPX gene, which is part of the sushi repeat-containing protein family. SRPX is a transmembrane or secreted protein containing conserved sushi domains, known to mediate protein-protein interactions. Initially linked to brain development, SRPX is expressed in neurons, glial cells, and various tissues, including the kidneys and lungs. It plays roles in cell adhesion, migration, and signaling, with emerging ties to synaptic function and neural circuit formation.

Mutations in SRPX are associated with neurological disorders. For example, SRPX loss-of-function variants are linked to Rolandic epilepsy, speech apraxia, and language impairments. Additionally, SRPX dysregulation is observed in cancers, particularly gliomas, where it may promote tumor angiogenesis and invasion via interactions with extracellular matrix components or growth factor pathways.

SRPX antibodies are primarily used as research tools to study the protein's expression, localization, and function in normal and diseased states. They aid in detecting SRPX in tissue samples, cell cultures, or animal models, contributing to mechanistic insights into its role in neurodevelopment, epilepsy, and cancer progression. Some studies also explore SRPX antibodies for potential therapeutic applications, such as blocking oncogenic signaling in tumors. However, their clinical utility remains under investigation, with ongoing research needed to validate specificity and efficacy.