SRPRB抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Jurkat cells, Hela cells, 293T cells, 231 cells, HepG2 cells, Human normal liver tissue, Human bladder carcinoma tissue, Primary antibody: P08770(SRPRB Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08770(SRPRB Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08770(SRPRB Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SRPRB (Signal Recognition Particle Receptor B subunit) antibody targets a key component of the cellular protein translocation machinery. SRPRB, also known as SRβ, is a subunit of the signal recognition particle receptor (SRP receptor), a heterodimeric complex located on the endoplasmic reticulum (ER) membrane. This receptor facilitates the co-translational targeting of secretory and membrane proteins to the ER by mediating the interaction between the signal recognition particle (SRP)-ribosome-nascent polypeptide complex and the translocon. SRPRB functions as a GTPase, regulating the receptor's assembly and disassembly during the protein translocation cycle.

Antibodies against SRPRB are essential tools for studying ER-associated protein transport, cellular stress responses, and diseases linked to defective protein secretion, such as certain cancers and neurodegenerative disorders. They enable researchers to detect SRPRB expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation, providing insights into its localization, interaction partners, and regulatory mechanisms. Studies using SRPRB antibodies have also explored its role in ER-phagy (selective autophagy of the ER) and cellular adaptation to nutrient deprivation. Commercial SRPRB antibodies are typically validated for specificity across human, mouse, and rat models, supporting cross-species translational research.