SHPRH抗体—艾普蒂

The SHPRH (SNF2 Histone Linker PHD RING Helicase) antibody is a tool used to study the SHPRH protein, a critical player in DNA damage repair and genomic stability. SHPRH, a member of the SWI/SNF family of helicases, functions as an E3 ubiquitin ligase that collaborates with the PCNA (Proliferating Cell Nuclear Antigen) to regulate error-free DNA repair pathways. It promotes the polyubiquitination of PCNA, facilitating the switch from translesion DNA synthesis to homologous recombination repair during replication stress. Discovered as a human homolog of yeast Rad5. SHPRH mutations or dysregulation have been linked to cancer susceptibility, neurodevelopmental disorders, and premature aging phenotypes. Antibodies targeting SHPRH enable researchers to investigate its expression, localization, and interactions in cellular contexts, particularly in studies involving DNA replication stress, tumorigenesis, and chemotherapeutic resistance. These antibodies are vital for techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, helping to elucidate SHPRH’s role in maintaining genome integrity and its potential as a therapeutic target in cancers with defective DNA repair mechanisms.