DNAJA3抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08760(DNAJA3 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The DNAJA3 antibody is a research tool used to detect and study the DNAJA3 protein, a member of the Hsp40 (heat shock protein 40) family. DNAJA3. also known as Tid1. functions as a co-chaperone for Hsp70. aiding in protein folding, degradation, and cellular stress responses. It plays a critical role in mitochondrial homeostasis, apoptosis, and quality control of misfolded proteins. Dysregulation of DNAJA3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.

Antibodies targeting DNAJA3 enable researchers to investigate its expression, localization, and interactions in cells or tissues. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies using DNAJA3 antibodies have revealed its tumor-suppressive roles in certain cancers, where it modulates oncogenic signaling pathways like Ras and EGFR. Additionally, its involvement in mitochondrial dynamics and stress adaptation highlights its importance in cellular resilience.

The development and validation of DNAJA3-specific antibodies are essential for understanding its molecular mechanisms and therapeutic potential. Commercial DNAJA3 antibodies vary in host species, clonality, and conjugation, allowing flexibility in experimental design. Ongoing research aims to clarify its tissue-specific functions and explore its role as a biomarker or therapeutic target in diseases linked to proteostasis imbalance.