S100A14抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08733(S100A14 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of S100A14 Antibody**

S100A14. a member of the S100 calcium-binding protein family, is encoded by the *S100A14* gene located on human chromosome 1q21. This protein is implicated in diverse cellular processes, including cell proliferation, differentiation, and extracellular signaling, often through interactions with intracellular targets like p53 and extracellular matrix components. Dysregulation of S100A14 has been linked to multiple cancers, such as breast, colorectal, and oral squamous cell carcinoma, where it may act as either an oncogene or tumor suppressor depending on the tissue context.

S100A14 antibodies are essential tools for detecting and quantifying S100A14 expression in research and diagnostics. These antibodies, typically raised in rabbits or mice, are validated for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Their specificity enables the study of S100A14’s role in tumor progression, metastasis, and its interaction with signaling pathways like EGFR and NF-κB. Recent studies also explore its potential as a biomarker for cancer prognosis or therapeutic targeting.

Despite its emerging significance, S100A14's functional mechanisms remain partially understood, necessitating further research. Reliable antibodies are critical for elucidating its dual roles in cancer and normal physiology, aiding the development of targeted therapies.