S100A11抗体—艾普蒂

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hepg2 cells, A549 cells, Primary antibody: P08730(S100A11 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P08730(S100A11 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

S100A11. a member of the S100 calcium-binding protein family, plays diverse roles in cellular processes such as proliferation, differentiation, apoptosis, and inflammation regulation. It functions as a calcium sensor, modulating intracellular signaling pathways through interactions with target proteins like annexins and cytoskeletal components. S100A11 is implicated in cancer progression, where its expression is often dysregulated, correlating with tumor invasiveness, metastasis, and poor prognosis in cancers such as gastric, ovarian, and colorectal carcinomas. It also participates in membrane repair, calcium homeostasis, and immune responses.

Antibodies against S100A11 are critical tools for studying its expression, localization, and functional mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in both research and diagnostic applications. Commercially available S100A11 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes to ensure specificity. Validation includes testing on recombinant proteins or knockout cell lines to confirm minimal cross-reactivity with other S100 family members.

Research using S100A11 antibodies has revealed its dual role in cancer—acting as either an oncogenic promoter or tumor suppressor, depending on context. Additionally, studies explore its involvement in inflammatory diseases and cellular stress responses. Ongoing efforts focus on developing therapeutic strategies targeting S100A11 or its pathways, particularly in oncology. Reliable antibodies remain essential for unraveling its complex biology and translational potential.