RPLP2抗体—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08722(RPLP2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ribosomal protein lateral stalk subunit P2 (RPLP2) is a component of the 60S ribosomal subunit, belonging to the acidic ribosomal phosphoprotein (P-protein) family. It forms a heterodimer with RPLP1. anchoring the ribosomal GTPase-associated center critical for translation elongation and termination. RPLP2 is ubiquitously expressed in eukaryotic cells and plays a structural role in ribosome assembly while interacting with elongation factors during protein synthesis.

Antibodies targeting RPLP2 are widely used to study ribosome biogenesis, cellular stress responses, and translational regulation. They serve as tools for detecting RPLP2 expression in Western blotting, immunofluorescence, and immunohistochemistry. Due to its conserved sequence across species, RPLP2 antibodies often exhibit cross-reactivity in human, mouse, rat, and other model organisms.

In disease research, RPLP2 has been implicated in cancers, with studies linking its overexpression to tumor progression and chemoresistance. Commercial RPLP2 antibodies (e.g., from Santa Cruz Biotechnology, Abcam, or Cell Signaling Technology) are typically validated for specificity using knockdown/knockout controls. Researchers should verify antibody performance in their experimental systems, as post-translational modifications (e.g., phosphorylation) or alternative splicing variants may affect detection. Some antibodies may cross-react with paralogs like RPLP1. necessitating careful optimization of protocols.