RPL15抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08720(RPL15 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The RPL15 antibody is a crucial tool in studying ribosomal protein L15 (RPL15), a component of the 60S ribosomal subunit involved in protein synthesis. RPL15. encoded by the RPL15 gene, belongs to the L15E ribosomal protein family and plays roles in ribosome assembly, mRNA binding, and translational fidelity. Beyond its canonical function, RPL15 has been implicated in various pathological conditions, including cancer. Dysregulation of RPL15 expression has been observed in malignancies such as esophageal squamous cell carcinoma, breast cancer, and multiple myeloma, where it may promote tumor progression by modulating oncogenic signaling pathways or interacting with non-ribosomal proteins.

Antibodies targeting RPL15 are widely used in research to investigate its expression patterns, subcellular localization, and interactions. They enable techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP). Validated RPL15 antibodies are essential for distinguishing between ribosomal and potential non-ribosomal functions, particularly in studies exploring its dual roles in translation and disease mechanisms. Specificity is typically confirmed using knockout cell lines or siRNA-mediated knockdown controls. Commercial RPL15 antibodies are often raised against conserved regions of the human protein, with cross-reactivity tested in model organisms like mice and rats. Recent studies also highlight its potential as a biomarker or therapeutic target, emphasizing the antibody's diagnostic and research relevance.