ROBO4抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08718(ROBO4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08718(ROBO4 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of ROBO4 Antibody**

ROBO4 (Roundabout homolog 4) is a transmembrane receptor belonging to the Roundabout (Robo) family, which plays critical roles in vascular development and angiogenesis. Primarily expressed in endothelial cells, ROBO4 regulates cell migration, adhesion, and vascular stabilization by interacting with its ligands, such as Slit proteins and other non-Slit ligands (e.g., UNC5B). Unlike other Robo receptors, ROBO4 is largely restricted to the vascular system and is involved in maintaining endothelial barrier integrity and modulating pathological angiogenesis.

ROBO4 gained attention for its dual role in both promoting and inhibiting angiogenesis, depending on cellular context and ligand interactions. Studies highlight its importance in embryonic vascular development and its re-emergence in adult endothelial cells during diseases like cancer, diabetic retinopathy, and inflammatory disorders. ROBO4 signaling often intersects with pathways like VEGF and Wnt, making it a potential therapeutic target.

ROBO4 antibodies are essential tools for detecting ROBO4 expression in vascular tissues, studying its function in angiogenesis assays, and exploring its therapeutic potential. These antibodies enable researchers to investigate ROBO4's role in endothelial cell behavior, vascular permeability, and disease mechanisms. Recent research also explores ROBO4-targeted therapies to normalize tumor vasculature or block pathological angiogenesis, underscoring its clinical relevance in vascular-related diseases.