RASA1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08671(RASA1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08671(RASA1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The RASA1 antibody is designed to detect RAS p21 protein activator 1 (RASA1), a critical regulatory protein involved in the RAS/MAPK signaling pathway. RASA1. also known as p120-RasGAP, functions as a GTPase-activating protein (GAP) that negatively regulates RAS activity by accelerating its intrinsic GTPase activity, thereby converting active GTP-bound RAS to its inactive GDP-bound form. This regulation is essential for controlling cellular processes such as proliferation, differentiation, and apoptosis. Mutations or dysregulation of RASA1 are linked to vascular malformations, including capillary malformation-arteriovenous malformation (CM-AVM) syndrome, and have been implicated in certain cancers due to aberrant RAS signaling.

RASA1 antibodies are widely used in research to study protein expression, localization, and function in various tissues and disease models. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These tools help elucidate RASA1's role in vascular development, tumor suppression, and signal transduction mechanisms. Additionally, RASA1 antibodies contribute to diagnostic investigations of genetic disorders and potential therapeutic strategies targeting RAS pathway dysregulation. Their specificity and reliability make them vital for advancing understanding of RASA1-related pathologies and cellular signaling networks.