PYGM抗体—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: P08658(PYGM Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08658(PYGM Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08658(PYGM Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

PYGM antibody targets the muscle isoform of glycogen phosphorylase (PYGM), a key enzyme in glycogenolysis. PYGM, encoded by the *PYGM* gene on chromosome 11q13. catalyzes the breakdown of glycogen into glucose-1-phosphate in skeletal muscle, providing energy during intense physical activity. Mutations in *PYGM* are linked to McArdle disease (glycogen storage disease type V), a rare autosomal recessive disorder characterized by exercise intolerance, muscle cramps, and myoglobinuria due to impaired glycogen metabolism.

PYGM antibodies are essential tools in research and diagnostics. They enable the detection and quantification of PYGM protein expression in muscle tissues via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in studying PYGM’s role in energy metabolism, muscle function, and disease mechanisms. Commercially available PYGM antibodies are typically raised in rabbits or mice, produced as monoclonal or polyclonal forms, and validated for specificity against human or model organism samples.

Clinically, PYGM antibodies assist in confirming McArdle disease diagnoses by identifying reduced or absent PYGM protein in muscle biopsies. Research applications also extend to exploring metabolic disorders, exercise physiology, and therapeutic strategies targeting glycogen storage diseases. Understanding PYGM regulation and dysfunction through antibody-based assays contributes to advancing treatments for muscle-related metabolic conditions.