PTP4A1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08643(PTP4A1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

**Background of PTP4A1 Antibody**

PTP4A1 (Protein Tyrosine Phosphatase 4A1), also known as PRL-1. is a member of the protein tyrosine phosphatase (PTP) family, which plays critical roles in regulating cellular signaling pathways. Unlike classical PTPs, PTP4A1 belongs to the phosphatases of regenerating liver (PRL) subfamily, characterized by a unique C-terminal prenylation motif (CAAX box) that influences its subcellular localization. PTP4A1 is implicated in diverse cellular processes, including cell proliferation, migration, and metastasis, often through interactions with oncogenic signaling pathways such as MAPK and PI3K/AKT. Overexpression of PTP4A1 has been observed in multiple cancers (e.g., colorectal, breast, and liver cancers), correlating with poor prognosis and aggressive tumor behavior.

Antibodies targeting PTP4A1 are essential tools for studying its expression, localization, and functional roles in both normal and pathological contexts. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the exploration of PTP4A1's involvement in cancer progression and its potential as a therapeutic target. Recent studies also investigate its role in non-cancerous conditions, such as metabolic disorders. Despite its established oncogenic properties, the precise molecular mechanisms of PTP4A1 remain under investigation, highlighting the continued need for reliable antibodies to advance research and diagnostic applications.