POT1抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08634(POT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08634(POT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The POT1 (Protection of Telomeres 1) antibody is a critical tool for studying telomere biology and associated diseases. POT1. a component of the shelterin complex, binds single-stranded telomeric DNA via its oligonucleotide/oligosaccharide-binding (OB) folds, playing a vital role in telomere maintenance and genomic stability. It regulates telomere length by inhibiting telomerase activity and preventing DNA damage response activation. Dysregulation or mutations in POT1 are linked to cancers (e.g., melanoma, leukemia) and inherited disorders like familial POT1 deficiency syndromes, characterized by premature aging and telomere dysfunction.

POT1 antibodies are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect POT1 expression levels, localization, and interactions in cells or tissues. These antibodies help elucidate POT1's role in telomere protection, replication stress response, and oncogenesis. Researchers also employ them to study how POT1 dysfunction contributes to telomere shortening, chromosomal instability, and disease progression. Commercial POT1 antibodies are typically validated for specificity and sensitivity across species (human, mouse), with applications in basic research and clinical diagnostics. Recent studies focus on POT1's therapeutic potential, as targeting telomere maintenance mechanisms may offer novel strategies for cancer treatment and anti-aging therapies.