MSMB抗体—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human prostate tissue, Primary antibody: P08613(MSMB Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08613(MSMB Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08613(MSMB Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

Microseminoprotein-beta (MSMB), also known as β-microseminoprotein, is a small secretory protein primarily expressed in the prostate gland. It was first identified in seminal plasma and is involved in regulating semen liquefaction and immune modulation. MSMB has garnered significant attention due to its potential role as a biomarker, particularly in prostate cancer. Research indicates that MSMB expression is frequently downregulated in prostate tumors, correlating with disease progression and poor prognosis. This suppression is linked to hypermethylation of the MSMB promoter or genetic variations, such as the rs10993994 SNP.

MSMB antibodies are critical tools for detecting and quantifying MSMB protein levels in research and diagnostics. Polyclonal and monoclonal antibodies targeting specific epitopes of MSMB enable applications like immunohistochemistry, ELISA, and Western blotting. These antibodies help elucidate MSMB's biological functions, including its interaction with cysteine-rich secretory protein 3 (CRISP-3) and possible roles in apoptosis and tumor suppression.

Clinically, MSMB antibodies are explored for early cancer detection, monitoring therapeutic responses, and developing targeted therapies. Challenges include ensuring antibody specificity due to MSMB's structural homology with other semenogelin proteins. Ongoing studies aim to optimize MSMB-based assays and validate their utility in precision oncology, highlighting its dual significance in basic research and translational medicine.