PCMT1抗体—艾普蒂

The PCMT1 antibody targets protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 (PCMT1), also known as protein carboxyl methyltransferase 1 or PIMT. This enzyme plays a critical role in repairing damaged proteins by catalyzing the methylation of abnormal isoaspartyl residues, which arise spontaneously from asparagine deamidation or aspartate isomerization. PCMT1-mediated repair helps maintain protein structural integrity and functionality, particularly under cellular stress or aging conditions. The PCMT1 antibody is widely used in research to study protein quality control mechanisms, aging-related protein damage, and neurodegenerative disorders like Alzheimer’s and Parkinson’s diseases, where protein misfolding and aggregation are prominent. It is employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect PCMT1 expression levels and localization in tissues or cultured cells. Studies using this antibody have highlighted PCMT1’s presence in both cytoplasmic and mitochondrial compartments, suggesting its role in diverse cellular environments. Additionally, PCMT1 knockout models and antibody-based assays have linked its activity to stress resilience and lifespan regulation in experimental organisms. The antibody serves as a vital tool for exploring PCMT1’s therapeutic potential in mitigating age-related protein damage or metabolic disorders.