PARL抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08599(PARL Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08599(PARL Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

PARL (Presenilin-associated rhomboid-like) antibody is a tool used to detect the PARL protein, a mitochondrial intramembrane serine protease belonging to the rhomboid family. PARL is primarily located in the inner mitochondrial membrane and plays critical roles in mitochondrial quality control, dynamics, and apoptosis. It processes substrates such as PGAM5 (a phosphatase involved in necroptosis) and regulates mitofusin degradation, impacting mitochondrial fusion-fission balance. PARL also participates in the cleavage of PINK1. a kinase linked to Parkinson’s disease, influencing PINK1/Parkin-mediated mitophagy. Dysregulation of PARL has been implicated in neurodegenerative disorders, metabolic syndromes, and cancer.

PARL antibodies are essential for studying these processes, enabling researchers to analyze PARL expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Specific antibodies (e.g., monoclonal or polyclonal) are validated for species reactivity (human, mouse, rat) and application-specific performance. Recent studies highlight PARL's role in mitochondrial stress responses, making its antibody a valuable reagent for exploring disease mechanisms and therapeutic targets. Quality validation (e.g., knockout controls) ensures antibody specificity, crucial for accurate experimental outcomes in mitochondrial biology research.