PAGE5抗体—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08594(PAGE5 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The PAGE5 (P antigen family member 5) antibody is a tool used to detect the PAGE5 protein, which belongs to the cancer/testis antigen (CTA) family. CTAs like PAGE5 are typically expressed in germ cells of the testis but are silenced in most somatic tissues. However, they are often aberrantly re-expressed in various cancers, making them potential biomarkers and therapeutic targets. PAGE5. encoded by the *PAGE5* gene on the X chromosome, shares structural features with other CTAs, including a conserved GAGE/PAGE domain. Its expression has been documented in prostate cancer, melanoma, and other malignancies, where it may contribute to tumor progression or immune evasion.

Research on PAGE5 antibodies focuses on understanding its biological role, tissue-specific expression patterns, and clinical relevance. These antibodies are used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to study PAGE5 localization and expression levels in normal versus cancerous tissues. Additionally, PAGE5 antibodies may aid in developing diagnostic assays or immunotherapies, as CTAs are being explored for cancer vaccines or T cell-based therapies due to their tumor-restricted expression. Despite its potential, PAGE5's functional mechanisms remain poorly characterized, necessitating further studies to clarify its oncogenic role and therapeutic utility.